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Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 9th Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 9th Edition

John P. Bilezikian (Editor)

ISBN: 978-1-119-26656-3

Oct 2018, Wiley-Blackwell

1168 pages




Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 9th Edition is the comprehensive revision of the field-leading reference on bone and mineral health. The eighth edition has been fully revised by the leading researchers and clinicians in the field to provide concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. Chapters look to explain basic biological factors of healthy development and disease states and make it easily translatable to clinical interventions. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease.


Preface to the Ninth Edition of the Primer: John P. Bilezikian, MD, PhD (hon)


President’s Preface: Michael J. Econs, MD

About the Companion Website

 Section I. Molecular and Cellular Determinants of Bone Structure and Function

1 Early Skeletal Morphogenesis in Embryonic Development

2 Endochondral ossification

3 Local and Circulating Osteoprogenitor Cells and Lineages

4 Osteoblasts

5 Osteocytes

6 Osteoclast Biology and Bone Resorption

7 Signal Transduction Cascades Controlling Osteoblast Differentiation

8 The TGFβ superfamily in bone formation and maintenance

9 Recent Developments in Understanding the Role of Wnt Signaling in Skeletal Development and Disease

10 Mechanotransduction in bone formation and maintenance

11 The Composition of Bone

12 Assessment of Bone Mass, Structure, and Quality in Rodents

13 Skeletal Healing: Cellular and Molecular Determinants

14 Biomechanics of Fracture Healing

Section II. Skeletal Physiology

15 Human Fetal and Neonatal Bone Development

16 Skeletal Growth: a Major Determinant of Bone’s Structural Diversity in Women and Men

17 Ethnic Differences in Bone Acquisition

18 Calcium, vitamin D and other nutrients during growth

19 Mechanical Loading and the Developing Skeleton

20 Pregnancy and Lactation

21 Menopause and age-related bone loss

Section III. Mineral Homeostasis

22 Regulation of Calcium Homeostasis

23 Magnesium Homeostasis

24 Fetal Calcium Metabolism

25 FGF23 and the Regulation of Phosphorus Metabolism

26 Gonadal Steroids

27 Parathyroid Hormone

28 Parathyroid Hormone-related Protein

29 Calcium-Sensing Receptor

30 Vitamin D: Production, Metabolism, Action, and Clinical Requirements

Section IV. Investigation of Metabolic Bone Diseases

31 Techniques of Bone Mass Measurement in Children with Risk Factors for Osteoporosis

32 Standard Techniques of Bone Mass Measurement in Adults

33 Advanced Techniques of Bone Mass Measurements and Strength in Adults

34 Magnetic Resonance Imaging of Bone

35 Trabecular Bone Score

36 Reference Point Indention

37 Biochemical markers of bone turnover in osteoporosis

38 Scintigraphy and PET in Metabolic Bone Disease

39 Bone Histomorphometry in Clinical Practice

40 Diagnosis and Classification of Vertebral Fracture

41 FRAX®: Assessment of Fracture Risk

Section V. Genetics of Bone

42 Introduction to Genetics

43 Animal Models: Genetic Manipulation

44 Animal Models: Allelic Determinants for BMD

45 Transcriptional Profiling for Genetic Assessment

46 Approaches to Genetic Testing

47 Human Genome-Wide Association Studies

48 Translational Genetics of Osteoporosis: From Population Association to Individualized Assessment

Section VI. Osteoporosis

49 Osteoporosis: An Overview

50 The Epidemiology of Osteoporotic Fractures

51 Fracture Liaison Service

52 Sex Steroids and the Pathogenesis of Osteoporosis

53 Juvenile Osteoporosis

54 Transplantation Osteoporosis

55 Premenopausal Osteoporosis

56 Osteoporosis in Men

57 Bone Stress Injuries

58 Inflammation–Induced Bone Loss in the Rheumatic Diseases

59 Glucocorticoid-Induced Osteoporosis

60 HIV and Bone

61 Skeletal Effects of Drugs

62 Diabetes and Bone Loss

63 Obesity and Skeletal Health

64 Sarcopenia and Osteoporosis

65 Fragility Fractures across the Five Stages of Chronic Kidney Disease

66 Other Secondary Causes of Osteoporosis

67 Exercise for osteoporotic fracture prevention and management

68 Prevention of Falls

69 Nutritional Support for Osteoporosis

70 Estrogens, Selective Estrogen Receptor Modulators and Tissue Selective Estrogen Complex

71 Bisphosphonates for Postmenopausal Osteoporosis

72 Denosumab

73 Parathyroid Hormone and Abaloparatide Treatment for Osteoporosis

74 Combination Anabolic and Antiresorptive Therapy for Osteoporosis

75 Strontium Ranelate and Calcitonin

76 Adverse Effects of Drugs for Osteoporosis

77 Orthopaedic Principles of Fracture Management

78 Adherence to Osteoporosis Therapies

79 The Cost-Effectiveness of Osteoporosis Treatment

80 Future Therapies

Section VII. Metabolic Bone Diseases

81 Approach to Parathyroid Disorders

82 Primary Hyperparathyroidism

83 Familial States of Primary Hyperparathyroidism

84 Non-Parathyroid Hypercalcemia

85 Hypocalcemia: Definition, Etiology, Pathogenesis, Diagnosis, and Management

86 Hypoparathyroidism

87 Pseudohypoparathyroidism

88 Disorders of Phosphate Homeostasis

89 Rickets and Osteomalacia

90 Pathophysiology and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder

91 Disorders of Mineral Metabolism in Childhood

92 Paget’s Disease of Bone

93 Epidemiology, Diagnosis, Evaluation and Treatment of Nephrolithiasis

94 Immobilization and Burns: Other Conditions Associated with Osteoporosis

Section VIII. Cancer and Bone

95 Mechanisms of Osteolytic and Osteoblastic Skeletal Lesions

96 Clinical and Preclinical Imaging in Osseous Metastatic Disease

97 Metastatic Tumors and Bone

98 Myeloma Bone Disease and Other Hematological Malignancies

99 Osteogenic Osteosarcoma

100 Skeletal Complications of Breast and Prostate Cancer Therapies

101 Bone Cancer and Pain

102 Radiation Therapy-Induced Osteoporosis

103 Skeletal Complications of Childhood Cancer

104 Medical Prevention and Treatment of Bone Metastases

105 Radiotherapy of Skeletal Metastases

106 Concepts and Surgical Treatment of Metastatic Bone Disease

Section IX. Sclerosing and Dysplastic Bone Diseases

107 Sclerosing Bone Disorders

108 Fibrous dysplasia

109 The Osteochondrodysplasias

110 Ischemic and Infiltrative Disorders of Bone

111 Tumoral Calcinosis-Dermatomyositis

112 Genetic Disorders of Heterotopic Ossification: Fibrodysplasia Ossificans Progressiva and Progressive Osseous Heteroplasia

113 Osteogenesis Imperfecta

114 Fibrillinopathies: Skeletal Manifestations of Marfan Syndrome and Marfan-related Conditions

115 Hypophosphatasia and Other Enzyme Deficiencies Affecting the Skeleton l

Section X. Oral and Maxillofacial Biology and Pathology

116 Craniofacial Morphogenesis Erin Ealba Bumann and Vesa

117 Development and Structure of Teeth and Periodontal Teeth

118 Craniofacial Disorders Affecting the Dentition: Genetic

119 Pathology of the Hard Tissues of the Jaws

120 Osteonecrosis of the Jaw

121 Alveolar Bone Homeostasis in Health and Disease

122 Oral Manifestation of Metabolic Bone Diseases

123 Dental Implants and Osseous Healing in the Oral Cavity

Section XI. Integrative Physiology of the Skeleton

124 Integrative Physiology of the Skeleton

125 The Hematopoietic Niche and Bone

126 Adipocytes and Bone

127 The Vasculture and Bone

128 Immunobiology and Bone

129 Cellular Bioenergetics of Bone

130 Endocrine Bioenergetics of Bone

131 Central Neuronal Control of Bone

132 Peripheral Neuronal Control of Bone

133 The Pituitary-Bone Axis in Health and Disease

134 Neuropsychiatric Disorders and the Skeleton

135 Interactions Between Muscle and Bone