Skip to main content

Organic Chemistry As a Second Language: Second Semester Topics, 4th Edition

Organic Chemistry As a Second Language: Second Semester Topics, 4th Edition

David R. Klein

ISBN: 978-1-119-23472-2

Dec 2015

400 pages



Readers continue to turn to Klein's Organic Chemistry As a Second Language: Second Semester Topics, 4th Edition because it enables them to better understand fundamental principles, solve problems, and focus on what they need to know to succeed. The fourth edition explores the major principles in the field and explains why they are relevant. It is written in a way that clearly shows the patterns in organic chemistry so that readers can gain a deeper conceptual understanding of the material. Topics are presented clearly in an accessible writing style along with numerous hands-on problem solving exercises.

Related Resources


Request an Evaluation Copy for this title

Contact your Rep for all inquiries

Chapter 1 Aromaticity 

1.1 Introduction to Aromatic Compounds 

1.2 Nomenclature of Aromatic Compounds

1.3 Criteria for Aromaticity 

1.4 Lone Pairs 

Chapter 2 IR Spectroscopy 

2.1 Vibrational Excitation 

2.2 IR Spectra

2.3 Wavenumber 

2.4 Signal Intensity 

2.5 Signal Shape 

2.6 Analyzing an IR Spectrum 

Chapter 3 NMR Spectroscopy 

3.1 Chemical Equivalence 

3.2 Chemical Shift (Benchmark Values) 

3.3 Integration 

3.4 Multiplicity 

3.5 Pattern Recognition 

3.6 Complex Splitting 

3.7 No Splitting 

3.8 Hydrogen Deficiency Index (Degrees of Unsaturation) 

3.9 Analyzing a Proton NMR Spectrum 

3.10 13C NMR Spectroscopy 

Chapter 4 Electrophilic Aromatic Substitution 

4.1 Halogenation and the Role of Lewis Acids 

4.2 Nitration 

4.3 Friedel-Crafts Alkylation and Acylation 

4.4 Sulfonation 

4.5 Activation and Deactivation 

4.6 Directing Effects 

4.7 Identifying Activators and Deactivators 

4.8 Predicting and Exploiting Steric Effects 

4.9 Synthesis Strategies 

Chapter 5 Nucleophilic Aromatic Substitution 

5.1 Criteria for Nucleophilic Aromatic Substitution 

5.2 SNAr Mechanism 

5.3 Elimination-Addition 

5.4 Mechanism Strategies 

Chapter 6 Ketones and Aldehydes 

6.1 Preparation of Ketones and Aldehydes 

6.2 Stability and Reactivity of C¨O Bonds 

6.3 H-Nucleophiles 

6.4 O-Nucleophiles

6.5 S-Nucleophiles 

6.6 N-Nucleophiles 

6.7 C-Nucleophiles 

6.8 Some Important Exceptions to the Rule 

6.9 How to Approach Synthesis Problems 

Chapter 7 Carboxylic Acid Derivatives 

7.1 Reactivity of Carboxylic Acid Derivatives 

7.2 General Rules

7.3 Acid Halides 

7.4 Acid Anhydrides 

7.5 Esters 

7.6 Amides and Nitriles 

7.7 Synthesis Problems 

Chapter 8 Enols and Enolates 

8.1 Alpha Protons 

8.2 Keto-Enol Tautomerism 

8.3 Reactions Involving Enols

8.4 Making Enolates 

8.5 Haloform Reaction 

8.6 Alkylation of Enolates 

8.7 Aldol Reactions 

8.8 Claisen Condensation 

8.9 Decarboxylation 

8.10 Michael Reactions 

Chapter 9 Amines 

9.1 Nucleophilicity and Basicity of Amines 

9.2 Preparation of Amines through SN2 Reactions 

9.3 Preparation of Amines through Reductive Amination 

9.4 Acylation of Amines 

9.5 Reactions of Amines with Nitrous Acid 

9.6 Aromatic Diazonium Salts 

Chapter 10 Diels-Alder Reactions 

10.1 Introduction and Mechanism 

10.2 The Dienophile 

10.3 The Diene 

10.4 Other Pericyclic Reactions 

Answer Key