Definitions of abbreviations
1. Heterocyclic nomenclature
2. Structures and spectroscopic properties of aromatic heterocycles
3. Substitutions of aromatic heterocycles
4. Organometallic heterocyclic chemistry
5. Methods in heterocyclic chemistry
6. Ring synthesis of aromatic heterocycles
7. Typical reactivity of pyridines, quinolines and isoquinolines
8. Pyridines: reactions and synthesis
9. Quinolines and isoquinolines: reactions and synthesis
10. Typical reactivity of pyrylium and benzopyrylium ions, pyrones and benzopyrones
11. Pyryliums, 2- and 4-pyrones: reactions and synthesis
12. Benzopyryliums, benzopyrones: reactions and synthesis
13. Typical reactivity of the diazines: pyridazine, pyrimidine and pyrazine
14. The diazines: pyridazine, pyrimidine, and pyrazine: reactions and synthesis
15. Typical reactivity of pyrroles, thiophenes, and furans
16. Pyrroles: reactions and synthesis
17. Thiophenes: reactions and synthesis
18. Furans: reactions and synthesis
19. Typical reactivity of indoles, benzo[b]thiophenes, benzo[b]furans, isoindoles, benzo[c]thiophenes and isobenzofurans
20. Indoles: reactions and synthesis
21. Benzo[b]thiophenes and benzo[b]furans: reactions and synthesis
22. Isoindoles, benzo[c]thiophenes and isobenzofurans: reactions and synthesis
23. Typical reactivity of 1,3- and 1,2-azoles and benzo-1,3- and -1,2-azoles
24. 1,3-Azoles: imidazoles, thiazoles, and oxazoles: reactions and synthesis
25. 1,2-Azoles: pyrazoles, isothiazoles, isoxazoles: reactions and synthesis
26. Benzanellated azoles: reactions and synthesis
27. Purines: reactions and synthesis
28. Heterocycles containing a ring-junction nitrogen (bridgehead compounds)
29. Heterocycles containing more than two heteroatoms
30. Saturated and partially unsaturated heterocyclic compounds: reactions and synthesis
31. Special topics
32. Heterocycles in biochemistry; heterocyclic natural products
33. Heterocycles in medicine
- The authors have thoroughly reviewed the material included in the earlier Editions, to make amendments in the light of new knowledge, and to include many important 21st Century advances
- Entirely, new sections include ‘Organometallic heterocyclic chemistry’, ‘Heterocycles in medicine’, reflecting the large part that heterocyclic chemistry plays in the pharmaceutical industry, and ‘Heterocycles in biochemistry; heterocyclic natural products’.
- Also included are new sections dealing explicitly with a number of topics important in the heterocyclic context: (i) heterocyclic fluorine compounds, (ii) isotopically labeled heterocycles, and (iii) the modern techniques of solid-phase chemistry, microwave heating and flow reactors.
- Two colour diagrams indicate where a change in structure or bonding has taken place, facilitating comprehension and understanding of the chemical changes that are occurring.
“Overall, this book is recommended as a text for undergraduate and more advanced students on this pervasive, important, and underappreciated topic in chemistry.” (Journal of Chemical Education, 1 October 2012)
"This excellent book is well written, heavily referenced, and thoroughly indexed. Accordingly, it serves as both an instructional heterocyclic chemistry textbook and a portal to the primary synthetic chemistry literature." (Journal of Medicinal Chemistry, 2011)
"My favourite chapter is the organometallic chemistry that presents an up-to-date treatment of the topic and helps confirms a colleague's observation that ‘With today's techniques one can be convinced that a modern organic chemist can make any small molecule he or she desires.' I particularly like the treatment of the concatenation of five-membered ring systems, an increasingly important area in medicinal chemistry. This chapter proves a real ‘coup de grace'." (Reviews, December 2010)
"In summary, Heterocyclic Chemistry by Joule and Mills is in a class of its own and can be thoroughly recommended as supplementary reading for undergraduate courses and as a first port of call for researchers seeking a quick entry to the extensive heterocyclic literature." (Applied Organometallic Chemistry, 2010)
"My recommendation is, even if you already have the 4th edition, to buy the latest version. At only £39.95 for the paperback version this is outstanding value for money." (Organic Process Research & Development Journal, 2010)
The use of colour in the schemes clearly highlights those parts of products (or intermediates) where a change in structure or bonding has taken place, facilitating comprehension and understanding of the chemical changes that are occurring.
Essential teaching material in the early chapters aims to capture the essence of heterocyclic reactivity in concise resumes suitable either as introductions, or as revisions/summaries for examination preparation.
Problems, divided into straightforward revision exercises and more challenging questions (with solutions as an Appendix), help the reader to understand and apply the principles of heterocyclic reactivity and synthesis.
All of the most significant heterocyclic chemistry of the 20th Century and many important 21st Century advances are covered.