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Ectoparasites: Drug Discovery Against Moving Targets

Ectoparasites: Drug Discovery Against Moving Targets

Charles Q. Meng (Editor), Ann E. Sluder (Editor), Paul M. Selzer (Series Editor)

ISBN: 978-3-527-80289-0

Jun 2018

720 pages

Select type: E-Book

$103.99

Description

This first book specifically dedicated to ectoparasite drug discovery is unique in providing insights from the veterinary as well as the medical perspective, covering research from both industry and academia while paving the way for new synergies between the two research communities.
Edited by a team combining 80 years of experience in academic research and industrial antiparasitic drug discovery, this volume of Drug Discovery in Infectious Diseases summarizes current knowledge in this rapidly expanding field. Comprehensive yet concise, this ready reference blends solid background information on ectoparasite biology with the very latest methods in ectoparasite drug discovery. Three major parts cover current ectoparasite control strategies and the threat of drug resistance, screening and drug evaluation, and the new isoxazoline class of ectoparasiticides. The future potential of mechanism-based approaches for repellents and parasiticides is thoroughly discussed, as are strategies for vaccines against ectoparasites, making the book ideal for parasitologists in academia as well as researchers working in the pharmaceutical industry.
PART I: NEED AND OPPORTUNITY IN ECTOPARASITE DRUG DISCOVERY
Challenges in preventing & treating ectoparasite infestations in human and animal health
Overview of major ectoparasites of humans and animals
Existing ectoparasite therapies in animal health and their extension to human health
The threat and reality of drug resistance

PART II: DISCOVERY SCREENING APPROACHES
Whole organism screens for ectoparasiticides
Repellency screens
Animal models
Testing repellents in humans

PART III: MOLECULAR TARGETS
Neuromuscular excitation and targets for knock-down parasiticides
Octopamine and tyramine receptors in acarids
The elusive DEET receptor
Ectoparasite odorant receptors as repellency targets

PART IV: NEW DEVELOPMENTS
Isoxazolines
Other chemical series in development
Anti-tick vaccines: Failed promise or unrealized opportunity?